在斯洛伐克高风险人群中成功实现LDL-C目标值:斯洛伐克脂质回顾性研究
Stefan Toth1, Martin Turek1, Daniel Pella2
1SLOVACRIN & MEDIPARK, Faculty of Medicine, Pavol Jozef Safarik University, Košice, Slovakia.
Archives of medical science : AMS
|July 31, 2025
概括
在斯洛伐克,90%以上患有非常高心血管风险的患者未能达到目标低密度脂蛋白胆固醇 (LDL-C) 水平. 强化降脂疗法对这些高危人群至关重要,以预防进一步的心血管事件.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 斯洛伐克面临高心血管死亡率,但关于失脂症管理有效性的数据很少.
- 对斯洛伐克非常高风险人口中脱脂症的欧洲指南的实施进行评估是必不可少的.
研究的目的:
- 评估在斯洛伐克的非常高心血管风险患者中达到目标低密度脂蛋白胆固醇 (LDL-C) 水平的程度.
- 评估欧洲心脏病学会/欧洲动脉样硬化学会 (ESC/EAS) 当前指导方针在这个人群中的有效性.
主要方法:
- 对72,039名患者 (2017-2019) 匿名的LDL-C测试结果的回顾性分析.
- 基于ICD诊断的心血管风险分层.
- 与2016年和2019年ESC/EASLDL-C目标建议对急性冠状动脉综合征 (ACS),中风和非常高心血管疾病风险组的评估.
主要成果:
- 超过90%的非常高心血管风险患者没有达到目标LDL-C水平.
- 只有8-10%的ACS或中风患者达到目标LDL-C.
- 使用2019年ESC/EAS指南进一步将目标实现率降低到每年2-3%.
结论:
- 目前,斯洛伐克非常高风险患者的脂质障碍症管理水平尚不理想,超过90%的患者未能达到LDL-C的目标.
- 2019年更严格的指导方针突出显示,对LDL-C控制的差距更大.
- 这些患者需要加强低血压治疗以减轻随后的心血管事件的风险.
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