通过超声波和微针滚筒增强了利多卡因奶油的通过皮肤传递
Jiaxiao Sun1, Yang Yang2,3, Juanjuan Zheng4
1Department of Anesthesiology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, Fujian, China.
Frontiers in bioengineering and biotechnology
|July 31, 2025
概括
微针滚筒与超声波相结合,显著增强了利多卡因通过皮肤输送,实现了快速麻醉. 这种组合为需要有效局部麻醉的时间敏感程序提供了有希望的方法.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 通过皮肤递送药物提供了一种非侵入性途径,用于管理利多卡因等局部麻醉剂.
- 优化物理参数对于提高通过皮肤输送利多卡因的疗效和速度至关重要.
- 现有的方法可能在实现快速和完全局部麻醉方面存在局限性.
研究的目的:
- 确定最有效的物理参数,以优化通过皮肤输送利多卡因奶油的输送.
- 评估超声波和微针滚筒在增强利多卡因透和麻醉效果方面的联合疗效.
- 为了比较不同的干预策略的通过皮肤输送和麻醉疗效.
主要方法:
- 在老鼠中使用视觉和组织病理学评估进行超声波参数的初步安全性和优化.
- 使用弗朗茨扩散细胞和共聚焦显微镜,对通过猪耳组织透利多卡因的ex vivo评估.
- 通过超声波和微针滚筒治疗后的老鼠尾部动试验,在老鼠皮肤中的利多卡因度和麻醉疗效的体内评估.
主要成果:
- 超声波 (260kHz,90%工作周期) 和微针滚筒的组合实现了最高的活体利多卡因透率 (15分钟时45.81±4.19μg/cm2).
- 同焦点显微镜显示,在5分钟内,在联合方法下,利多卡因的透深入皮肤显著增强.
- 在体内研究表明,联合方法导致麻醉最快 (28.75±6.41分钟) 和100%麻醉效率在60分钟.
结论:
- 微针滚筒,特别是与优化的超声波参数相结合时,在快速通过皮肤输送利多卡因方面表现出卓越的疗效.
- 这种方法使局部麻醉的开始明显更快,与对照组和仅超声组相比.
- 这些发现为时间敏感的程序建立了一个实用的范例,需要有效的透皮局部麻醉.
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