患者的临床形状的地理变化 氏球状光患者
Taylor Schieber1, Kaleb Roemer1, Kenneth Sands1
1HCA Healthcare, Nashville, TN, US.
概括
阳光菌感染正在增加. 这项研究比较了两个地区的患者结果,发现西部地区的死亡率更高,这两个地区都显示出高抗真菌耐药性.
科学领域:
- 传染性疾病 传染性疾病
- 医学真菌学 医学真菌学
- 医疗卫生流行病学 医疗卫生流行病学
背景情况:
- 阳光 (C. auris) 感染的发病率不断上升,对公众健康构成了重大挑战.
- C. auris是一种新兴的具有高死亡率的多药耐药性真菌病原体.
研究的目的:
- 在一个大型卫生系统中,在两个不同的地理区域中比较C. auris感染的临床结果和特征.
- 为了确定C. auris流行病学和患者管理的区域差异.
主要方法:
- 在2021年1月至2022年9月期间,对321例住院患者的C. auris感染病例进行了回顾性,多中心描述性分析.
- 西部和东部地区之间的临床结果比较,包括死亡率,机械通风,输血,血液透析,全腹腔营养和重症监护室 (ICU) 入院.
主要成果:
- 临床结果在很大程度上是可比的,除了西部地区 (32.1%) 与东部地区 (19.1%) 的较高死亡率或离院转移.
- 超过三分之一的患者需要机械呼吸,超过一半的患者接受了输血.
- 观察到高水平的血液透析 (25.2%),全腹腔营养 (24.3%),以及ICU入院 (> 50%). 抗可纳的C. auris在西部地区更为普遍,尽管两者都具有很高的耐药性.
结论:
- 黄菌感染与患者的显著发病率和疾病负担有关.
- 需要进一步的研究,以建立预防感染,减少传播和通过早期检测和向抗真菌治疗改善患者的治疗结果的最佳实践.
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