像蜂刺一样的可穿戴电网微针用于持续的中枢神经系统药物输送
Ji-Hwan Ha1,2, Yun-Woo Lee1,3, Soon Hyoung Hwang1
1Nano Lithography and Manufacturing Research Center, Korea Institute of Machinery and Materials (KIMM), Daejeon, 34103, Republic of Korea.
Advanced healthcare materials
|July 31, 2025
概括
可穿戴的电网微针 (EW-MN) 为持续的中枢神经系统 (CNS) 药物输送提供了一个舒适的解决方案. 这些以蜂刺剂为灵感的设备增强了药物扩散和有效性,用于持续的中枢神经系统疾病管理.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微针 (MNs) 提供最少的侵入性药物输送,但传统的刚性设计在持续使用时会引起不适.
- 通过MNs传递中枢神经系统 (CNS) 药物是有希望的,但受患者舒适性和设备可穿戴性限制.
研究的目的:
- 开发和评估可穿戴的电网微针 (EW-MN) 进行持续和舒适的中枢神经系统药物输送.
- 在中枢神经系统疾病模型中,评估EW-MNs在皮肤插入,药物扩散和治疗疗效方面的性能.
主要方法:
- 使用电纤维和接地金属微针用于皮肤固定的EW-MNs的制造.
- 评估透深度,使用光染料进行药物扩散,以及沿纤维表面持续释放药物.
- 在实验室和体内验证载有中枢神经系统向药物 (例如,里瓦斯蒂格明) 的EW-MN在几内亚猪模型中.
主要成果:
- EW-MNs展示了有效的皮肤插入和定,灵感来自蜜蜂刺机械.
- 证实了持续的药物释放,AUC增加了2.5倍,药物扩散区域扩大了五倍.
- 在体内研究证实了EW-MNs在持续的中枢神经系统疾病管理中的疗效.
结论:
- 可穿戴的EW-MNs提供了一个舒适而有效的平台,用于持续向中枢神经系统输送药物.
- 开发的EW-MN显示了通过增强药物输送来改善慢性中枢神经系统疾病的管理的巨大潜力.
相关概念视频
01:29Drug Delivery: Parenteral Route
841
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
841
01:22Drug Delivery: Miscellaneous Routes
468
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468