乘客淋巴细胞综合征 - 流行病学,发病,诊断,治疗和未来的方向:一个审查
Yingfang Pan1, Aiping Zhao2, Xiujiao Jiang2
1Blood Group Reference and Research Laboratory, Shandong Blood Center, Jinan,China; The First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, China.
Biomolecules & biomedicine
|July 31, 2025
概括
乘客淋巴细胞综合征 (PLS) 是一种移植并发症,在这种情况下,供体B细胞攻击接受者血液细胞,导致溶血性贫血. 治疗包括输血,皮质类固醇,有时还包括修复剂或血合成.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 乘客淋巴细胞综合征 (PLS) 是一种移植后的并发症.
- 它涉及捐赠者B淋巴细胞攻击接受者血液细胞,导致非免疫性.
- PLS呈现为血液溶解性贫血,具有特定的实验室发现.
研究的目的:
- 审查PLS的病理生理学.
- 检查PLS的诊断方法.
- 评估目前和未来的PLS治疗策略.
主要方法:
- 在Web of Science和PubMed的文献搜索PLS研究.
- 包括79项基于预先定义的标准的研究.
- 专注于人类捐赠者衍生的免疫和临床数据.
主要成果:
- PLS通常会导致溶血性贫血,升高的LDH,高 bilirubinemia,和低的Haptoglobin.
- 诊断依赖于临床症状,DAT和抗体查.
- 治疗包括输血,皮质类固醇,rituximab或等离子体合成.
结论:
- 治疗PLS的目的是阻止血液溶解并恢复血液平衡.
- 挑战包括延迟诊断和缺乏标准化的协议.
- 未来的研究应该专注于生物标志物和机制驱动疗法.
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