通过单片氧旋转翻转稳定染料敏感化上转化纳米系统
Chang Jiang1, Yang Li1, Tao Jia1
1MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering and Key Laboratory of Micro-systems and Micro-structures, Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China.
Small (Weinheim an der Bergstrasse, Germany)
|July 31, 2025
概括
稳定近红外染料敏感化的上转化纳米粒子 (UCNPs) 对生物应用至关重要. 这项研究引入了4-aminotriphenylamine (4A-TPA) 以防止单点氧损伤,显著提高了UCNP光稳定性,并实现了强大的生物成像.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 接近红外线 (NIR) 染料敏感化增强了兰化物增强转化纳米粒子 (UCNP) 的亮度.
- 染料敏感性UCNP的稳定性问题源于单片氧 (1O2) 对NIR染料的损伤.
研究的目的:
- 制定一种策略,以稳定染料敏感的UCNP,防止1O2诱导的降解.
- 提高UCNP在生物环境中的光稳定性和适用性.
主要方法:
- 将4-aminotriphenylamine (4A-TPA) 表面固定在UCNP上,以促进1O2旋转翻转.
- 利用富含电子的三烯胺组进行1O2吸附和系统间交叉.
- 用两性聚合物涂覆UCNPs,以获得水稳定性.
主要成果:
- 在30分钟的照射后,4A-TPA的结合使IR806敏感的UCNP的光稳定性提高了27倍.
- 增强的UCNP在高激光功率密度下 (1200W cm−2) 展示了稳定的细胞上转换发光成像.
- 该策略有效地保护了NIR染料免受1O2诱导的光降解.
结论:
- 表面固的4A-TPA提供了一种强大的方法,通过将有害的1O2转化为三重氧 (3O2) 来稳定染料敏感的UCNP.
- 这种稳定策略显著扩大了UCNP在先进生物成像和光动力学治疗应用中的潜力.
- 开发的纳米系统在水性介质中表现出增强的耐用性,这对于体内应用至关重要.
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