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解读慢性病与心脏之间相互作用的新兴信号通路:治疗挑战与机遇
Puneet Sharma1, Ch Sairam Choudhury1, Bidya Dhar Sahu1
1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research -Guwahati, Changsari, Assam, India.
Journal of biochemical and molecular toxicology
|July 31, 2025
概括
心脏病综合征 (CRS) 涉及心脏和脏功能障碍,影响整体健康. 本综述探讨了信号通路,以确定新的治疗点,以更好地管理CRS.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 分子生物学分子生物学
背景情况:
- 心脏病综合征 (CRS) 是一种全球性健康问题,其特点是心脏和功能障碍,导致多器官疾病和高死亡率.
- 目前的CRS治疗主要提供症状缓解,缺乏疾病修饰策略.
- 共享的病理生理机制将脏疾病和心脏功能障碍联系在一起,突出了针对性干预的必要性.
研究的目的:
- 审查和评估涉及到心脏病综合征 (CRS) 病理生理学的各种信号机制.
- 确定新的治疗目标和管理CRS的途径,超越症状治疗.
主要方法:
- 文献评估信号通路,包括Wnt/β-catenin,cGAS/STING,NLRP3炎症体,MAPK,ASK1,HDAC,PGC1α,α-klotho,FGF-23,以及氧化损伤.
- 分析这些途径在CRS的发展和进展中所起的作用.
主要成果:
- 在CRS中确定了具有保护性,渐进性或多样化作用的信号通路.
- 突出突出的新兴途径为新的治疗策略提供了潜力.
- 详细介绍了特定分子机制在CRS病变发生过程中的参与.
结论:
- 新兴的信号通路为开发特定和有效的CRS治疗提供了有希望的目标.
- 抑制剂分子用于疾病进展的标和激进分子用于保护性途径可以改变CRS管理.
- 这一审查为未来研究针对性疗法的基础,以减轻CRS和减少其影响.
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