在局部加热测试期间,糖尿病相关的脚光电脉冲图变化
Denis Lapitan1, Xiaoman Xing2,3, Alexey Glazkov1
1Moscow Regional Research and Clinical Institute ("MONIKI"), Moscow, Russia.
Journal of biophotonics
|July 31, 2025
概括
在局部加热过程中,光聚缩学 (PPG) 波形变化可以检测糖尿病患者的微血管损伤. 双色球的划痕是双色球的划痕
科学领域:
- 生物医学工程 生物医学工程
- 血管生理学 血管生理学
- 糖尿病研究 糖尿病研究
背景情况:
- 糖尿病与影响血液流动的微血管并发症有关.
- 摄影脉冲图 (PPG) 测量血液体积的变化,反映脉冲波形.
- 评估微血管功能对于管理糖尿病并发症至关重要.
研究的目的:
- 为了研究糖尿病患者局部皮肤加热期间PPG波形的变化.
- 评估PPG波形分析在糖尿病中检测微血管功能障碍的实用性.
主要方法:
- 试验对象包括健康人群,2型糖尿病和视网膜病变患者,以及2型糖尿病和足部综合征患者.
- 将大脚从32°C到42°C进行局部加热.
- 在加热前和加热期间,从两只四肢的大脚记录了PPG波形.
主要成果:
- 在加热后,在所有三组中都观察到PPG波形的统计学显著变化.
- 在PPG波形中的二突在加热期间变得更加明显.
- 这种效应在健康人群中最明显,在糖尿病视网膜病变患者中较少,在糖尿病足综合征患者中最小.
结论:
- 在局部加热测试期间监测PPG波形变化是评估糖尿病微血管病变的潜在方法.
- 在加热过程中二突增长的程度与微血管损伤的严重程度相关.
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