对于无法解释的复发植入失败患者的Ultimpro测试实施结果:单中心回顾性队列研究
Genevieve Genest1, Alyssa Hochberg2,3, Martine Boivin1,4
1Division of Clinical Immunology and Allergy, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada.
概括
无法解释的复发性植入失败 (uRIF) 患者在Ultimpro子宫内膜免疫类型测试中表现出更好的妊娠成功. 这种测试可以识别免疫失调,指导个性化胚胎移植协议,以在RurIF病例中获得更好的结果.
科学领域:
- 生殖免疫学 生殖免疫学
- 辅助生殖技术 辅助生殖技术
- 基因组学和蛋白质组学
背景情况:
- 一部分患有不明原因的复发性植入失败 (uRIF) 的患者可能会经历子宫内膜免疫失调.
- 该Ultimpro测试分析子宫内膜免疫类型,以检测和表征免疫失调.
- 根据Ultimpro的结果,可以根据胚胎移植 (ET) 协议提出个性化的调整.
研究的目的:
- 评估Ultimpro子宫内膜免疫类型测试在URIF患者中的有效性.
- 评估Ultimpro指导的协议是否可以改善与标准护理相比的怀孕和活产率.
- 为了比较接受Ultimpro测试的RIF患者和没有RIF患者的结局.
主要方法:
- 一个回顾性队列研究分析了121名患者超过2.5年.
- 第1组 (93名患者) 接受了URIF并接受了Ultimpro测试;结果与对照组 (94名URIF患者) 相比.
- 第二组 (28名没有RIF的患者) 与加拿大平均持续怀孕率 (OPR) 进行了比较.
主要成果:
- 第1组 (uRIF) 显示Ultimpro与对照组相比 (33%,p=0.026) 的怀孕率 (49.5%) 显着更高.
- 患有≥5次胚胎细胞移植失败的患者特别受益 (55.3%对20.0%,p=0.0084).
- 第2组 (没有RIF) 与非RIF平均值相比,没有改善每ET的OPR与Ultimpro建议.
结论:
- 初步发现表明,Ultimpro的建议可以改善RIF患者的成功结果.
- 该测试没有显示对没有RIF的患者有好处.
- 通过大规模随机对照试验进行进一步验证是有必要的.
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