阻塞性睡眠呼吸暂停和胸前大动脉直径之间的关联:在临床样本中的横截面研究
David C Cistulli1, Benjamin K Tong2, Philip J Currie3
1Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.
概括
阻塞性睡眠呼吸暂停 (OSA) 与较大的大动脉直径有关,特别是在女性中. 然而,像年龄和高血压这样的共同风险因素可能会解释这种关联,这需要对OSA和动脉动脉病进行进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 主动脉疾病 主动脉疾病
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为具有系统性影响.
- 以前的研究表明,OSA和大动脉扩张之间存在潜在的联系.
- 了解这种关联对于评估心血管风险至关重要.
研究的目的:
- 为了研究OSA严重程度和胸前大动脉尺寸之间的关系.
- 要确定OSA是否独立影响大动脉根和上升大动脉直径.
- 为了探索OSA-大动脉维度协会中的潜在性别差异.
主要方法:
- 分析了1470名接受心声学和多睡眠学治疗的患者队列.
- 对大动脉根和上升大动脉直径进行测量并根据OSA严重程度 (呼吸暂停-呼吸暂停指数) 进行比较.
- 进行了多变量分析和病例对照敏感性分析.
主要成果:
- 90%的患者患有OSA;大动脉根和上升大动脉直径随着OSA的严重程度增加 (p<0.01).
- 当以身高为指数时,关联仍然很重要,但不是身体表面积.
- 在女性中发现了一个独立的关联,但在男性中没有;然而,灵敏度分析发现轻度和严重的OSA之间没有显著差异.
结论:
- 这项最大规模的研究发现,大动脉直径增加,OSA严重程度更高.
- 分享的风险因素如年龄,BMI,高血压和心房动可能会混OSA-大动脉维度链接.
- 需要进一步的研究,以澄清OSA和大关节病之间的复杂关系,特别是关于性别特异性的影响.
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