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糖的消费会通过微生物组的破坏来消除癌症免疫疗法反应.

Kristin M Morder1, Madison Nguyen2, Drew N Wilfahrt1

  • 1University of Pittsburgh, Pittsburgh, PA, United States.

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饮食中的糖会影响肠道微生物,阻碍癌症免疫治疗的有效性. 通过氨基酸或便移植恢复肠道健康可以扭转这些负面影响,改善T细胞功能和治疗反应.

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科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 微生物组研究 微生物组研究

背景情况:

  • 肠道微生物群的组成会影响癌症免疫治疗的反应.
  • 饮食,特别是非营养甜味剂对这种关系的影响尚不清楚.

研究的目的:

  • 为了研究糖的消费如何影响肠道微生物群.
  • 确定对T细胞功能的下游影响和癌症免疫疗法的疗效.
  • 确定潜在的干预措施,以恢复免疫疗法反应.

主要方法:

  • 临床前癌症模型和晚期癌症患者接受抗PD-1免疫检查点抑制剂 (ICI) 治疗.
  • 对微生物组合和T细胞代谢的分析.
  • 涉及氨基酸补充和便微生物群转移 (FMT) 的干预研究.

主要成果:

  • 糖的消费改变了肠道微生物群的组成.
  • 糖摄入限制了T细胞代谢和功能,导致ICI反应减少.
  • 随着糖的使用,观察到微生物群可访问的氨酸的减少.
  • 从响应者中补充氨基酸或FMT恢复了T细胞功能和免疫治疗反应.

结论:

  • 苏克拉会破坏肠道微生物群的稳定,损害T细胞的功能.
  • 在癌症中,糖的消耗显著消除了抗PD-1免疫检查点抑制剂反应.
  • 准肠道微生物群和代谢途径是一个增强癌症免疫治疗的策略.