糖的消费会通过微生物组的破坏来消除癌症免疫疗法反应
Kristin M Morder1, Madison Nguyen2, Drew N Wilfahrt1
1University of Pittsburgh, Pittsburgh, PA, United States.
Cancer discovery
|July 31, 2025
概括
饮食中的糖会影响肠道微生物,阻碍癌症免疫治疗的有效性. 通过氨基酸或便移植恢复肠道健康可以扭转这些负面影响,改善T细胞功能和治疗反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物群的组成会影响癌症免疫治疗的反应.
- 饮食,特别是非营养甜味剂对这种关系的影响尚不清楚.
研究的目的:
- 为了研究糖的消费如何影响肠道微生物群.
- 确定对T细胞功能的下游影响和癌症免疫疗法的疗效.
- 确定潜在的干预措施,以恢复免疫疗法反应.
主要方法:
- 临床前癌症模型和晚期癌症患者接受抗PD-1免疫检查点抑制剂 (ICI) 治疗.
- 对微生物组合和T细胞代谢的分析.
- 涉及氨基酸补充和便微生物群转移 (FMT) 的干预研究.
主要成果:
- 糖的消费改变了肠道微生物群的组成.
- 糖摄入限制了T细胞代谢和功能,导致ICI反应减少.
- 随着糖的使用,观察到微生物群可访问的氨酸的减少.
- 从响应者中补充氨基酸或FMT恢复了T细胞功能和免疫治疗反应.
结论:
- 苏克拉会破坏肠道微生物群的稳定,损害T细胞的功能.
- 在癌症中,糖的消耗显著消除了抗PD-1免疫检查点抑制剂反应.
- 准肠道微生物群和代谢途径是一个增强癌症免疫治疗的策略.
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