相关实验视频

Updated: Sep 13, 2025

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

增加的二乙-4酶在慢性压力下的小鼠中促进脂肪炎症和功能障碍

Meiping Zhang¹, Huazhen Wang², Xiangdan Li³

¹Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|July 31, 2025

概括

慢性压力会导致脂肪炎症和功能障碍,但DPP4缺乏会扭转这些影响. DPP4抑制或GLP-1R刺激可以治疗压力较大的个体的代谢障碍.

科学领域:

代谢障碍代谢障碍代谢障碍
压力生理学压力生理学
脂肪组织生物学脂肪组织生物学

背景情况:

慢性心理压力是炎症和代谢疾病的重要危险因素.
滴样-4 (DPP4) 在受压力的组织中升级调节,并影响类似葡萄糖-1 (GLP-1) 的代谢.
在压力诱导的脂肪功能障碍中,DPP4/GLP-1轴的作用需要进一步研究.

研究的目的:

研究DPP4/GLP-1轴在慢性压力诱导的脂肪炎症和功能障碍中的作用.
为了研究DPP4缺乏对患有慢性压力的小鼠脂肪组织的影响.
评估DPP4抑制和GLP-1受体刺激的治疗潜力.

主要方法:

使用了野生型和DPP4敲击型小鼠,并对它们进行了固定压力.
进行了皮下脂肪组织 (SWAT) 的形态和生化分析.
评估了炎症,氧化应激和亡的分子标志物;评估了GLP-1受体激活剂exenatide在体内和体外的作用.

主要成果:

慢性压力导致SWAT重量减少,巨细胞透率增加,以及有害的分子变化 (氧化应激,亡,炎症标志物).
缺乏DPP4可以扭转这些压力引起的脂肪组织的有害变化.
在实验室中,exenatide治疗模仿了DPP4缺失的保护作用,减少了氧化应激和亡.

结论:

DPP4通过GLP-1/PI3K-AKT通路调解慢性压力诱导的脂肪炎症和功能障碍.
DPP4抑制和/或GLP-1受体刺激显示出治疗与慢性压力相关的代谢障碍的前景.
针对DPP4/GLP-1轴为与压力相关的代谢并发症提供了潜在的治疗策略.

关键词:

灭症 (apoptosis) 是一种死亡的过程.慢性压力是一种慢性压力.双基酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸-4-酸类似于葡萄糖的-1-1 这是一种炎症炎症炎症炎症.

更多相关视频

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

相关概念视频

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...