在接受癌症治疗的儿童骨肌肉的纵向变化:系统性审查和元分析
Anna Maria Markarian1,2, Dennis R Taaffe3,4, Daniel A Galvão3,4
1Exercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia. a.markarian@ecu.edu.au.
European journal of pediatrics
|July 31, 2025
概括
接受癌症治疗的儿童在治疗的早期经历了显著的骨肌肉损失. 这种下降凸显了需要精确的身体成分测量来监测儿科癌症患者和有效指导干预措施的需要.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症新陈代谢 癌症新陈代谢
- 身体组成分析 身体成分分析
背景情况:
- 成年癌症患者的骨肌损失与不良结果和生存率降低有关.
- 关于接受癌症治疗的儿童肌肉质量变化的数据有限且不一致.
研究的目的:
- 系统地审查和分析治疗期间儿童癌症患者骨肌肉变化的证据.
- 确定影响肌肉损失的因素,并为有风险的儿童提供有针对性的干预措施.
主要方法:
- 在CINAHL,Embase,PubMed,SPORTDiscus和Web of Science数据库中进行系统搜索.
- 包括20项研究 (n=646) 的儿科患者 (<19岁) 和至少两次肌肉量测量.
- 使用纽卡斯尔-太华尺度评估的方法质量.
主要成果:
- 在癌症治疗的早期阶段观察到骨肌量显著下降 (SMD = -0.36,p < 0.05).
- 在以后的随访点 (SMD = -0.08,p = 0.36) 总体肌肉变化没有统计学意义.
- 根据使用的身体组成评估方法,肌肉量估计有显著差异 (p = 0.048).
结论:
- 患有癌症的儿童在密集治疗阶段表现出显著的骨肌肉损失.
- 在后期阶段观察到的肌肉衰减似乎很小,但结果因评估方法而异.
- 标准化和可靠的身体成分测量对于准确的监测和儿科癌症护理中的临床决策至关重要.
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