具有遗传倾向的男性在接触电磁辐射时面临更大的生育挑战
Samudra Pal1,2, Pranab Paladhi1, Saurav Dutta1
1Cytogenetics & Genomics Research Unit, Department of Zoology, University of Calcutta, Taraknath-Palit-Siksha-Prangan, Ballygunge Science College Campus,35 Ballygunge Circular Road, Kolkata, 700019, West Bengal, India.
Molecular biology reports
|July 31, 2025
概括
关键介质基因 (SPO11,RNF212,SYCP3) 的遗传变异与电子辐射暴露相结合,会增加亚精子症的风险,特别是在老年男性中. 这一发现有助于男性不孕症管理.
科学领域:
- 生殖遗传学 生殖遗传学
- 环境健康 环境健康
- 男性不孕症研究研究
背景情况:
- 阴精缺失,即射精中缺少精子,是男性不孕症的重要原因之一.
- 遗传因素和环境暴露与亚精子症的病因有关.
- 核心介质调节基因在成功的精子生产中起着至关重要的作用.
研究的目的:
- 研究SPO11,RNF212和SYCP3基因中遗传变异的综合影响.
- 评估这些基因变异与电子辐射暴露对亚精子症的协同作用风险.
- 分析印度西孟加拉邦的孟加拉语男性的这些因素.
主要方法:
- 使用桑格序列测序对708个亚精子个体和640个对照个体进行基因定型.
- 在SPO11,RNF212和SYCP3.3中识别特定的遗传变异.
- 二元逻辑回归用于分析遗传变异,电子辐射和年龄之间的相互作用.
主要成果:
- 在介质调节器的遗传变异和亚精子症风险之间发现了显著的关联.
- 在30岁以上暴露于电子辐射的男性中观察到风险增加,这表明了协同效应.
- 电子辐射可能会恶化介质错误并损害胚胎细胞的发育,降低生育能力.
结论:
- 携带SPO11,RNF212和SYCP3的遗传变异,加上电子辐射暴露,会增加亚精子症的风险,特别是随着年龄的增长.
- 这些发现可以为男性不孕症的辅助生殖技术 (ART) 查和管理策略提供信息.
- 突出了男性生殖健康中遗传倾向和环境因素之间的相互作用.
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