在9至15岁的子女中,围产期母亲的抑郁症状和大脑连接性
Dogukan Koc1,2, Adriana P C Hermans1,2, Bing Xu1,2
1The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
JAMA network open
|July 31, 2025
概括
产前母亲的抑郁症状与儿童从童年中期到青春期的功能性大脑连接发展的改变有关. 产后症状没有显著的关联,这强调了产前母亲心理健康对后代神经发育的重要性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 孕期和产后母亲的抑郁症状与后代的神经发育结果有关.
- 产前/产后母亲抑郁症与后代功能性大脑网络发育之间的长度关联仍然不清楚.
研究的目的:
- 调查产前和产后母亲抑郁症状与子女从童年中期到青春期的功能性大脑连接的发育轨迹的关联.
主要方法:
- 在荷兰,基于人口的前性队列研究 (R世代).
- 包括2825个母婴二极管与静止状态功能磁共振成像 (fMRI) 扫描在两个时间点 (年龄9-15岁).
- 在怀孕期间和分娩后2,6个月评估母亲抑郁症状;使用图形理论指标分析后代大脑连接.
主要成果:
- 产前母亲的抑郁症状与后代大脑网络的全球效率和模块化增加有关.
- 发现与网络内默认模式网络连接有显著的关联.
- 在产后母亲的抑郁症状方面没有观察到任何显著的关联.
结论:
- 产前母亲的抑郁症状与子女功能性大脑连接的发育轨迹改变有关.
- 这些发现强调了产前母亲心理健康在塑造后代神经发育中的关键作用.
- 进一步的研究可能会探索针对产前母亲抑郁症的干预措施,以支持健康的大脑发育.
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