一项初步的综合代谢学分析确定了重度OSA患者逆行性内分类素信号转移
Li Han1,2, Jinjin Liu1,3, Juan Xu1,4
1PCCM, The Second Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Sleep & breathing = Schlaf & Atmung
|July 31, 2025
概括
严重的阻塞性睡眠呼吸暂停 (OSA) 显著影响新陈代谢,改变了许多途径. 该研究发现,在严重的OSA患者中,逆行性内分泌大麻素信号通路发生了变化,这表明了更广泛的全身效应.
科学领域:
- 代谢学 代谢学 代谢学
- 睡眠医学 睡眠医学
- 氧化压力是一种氧化压力.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA),特别是严重的OSA (sOSA),具有经常被忽视的全身影响.
- 了解SOSA中的代谢障碍对于全面的患者护理至关重要.
研究的目的:
- 研究成年OSA患者的活性氧物种 (ROS) 和代谢变化.
- 探索ROS,代谢变化和OSA严重程度之间的相互关系.
主要方法:
- 在22名男性OSA患者中进行了多睡眠图像 (PSG) 和血液样本分析.
- 在多态核核中性粒细胞 (PMN) 中测量ROS.
- 使用气体染色学-质谱学 (GC-MS) 和液体染色学-质谱学 (LC-MS) 的等离子体代谢分析.
主要成果:
- 严重的OSA患者表现出更高的BMI和较差的PSG指标.
- 睡眠碎片化与ROS产生的相关性.
- 在sOSA中观察到59个GC-MS和27个LC-MS代谢物的显著变化.
- 受影响的关键通路包括FoxO和PI3K-Akt信号传输.
- 逆行性内分类素信号传递是GC-MS和LC-MS分析中受到影响的常见途径.
结论:
- 严重的OSA会导致广泛的代谢途径障碍.
- 在sOSA中改变的逆行性内分泌大麻素信号表明了显著的系统性影响.
- 这项研究突出显示了OSA超出呼吸道影响的系统性影响.
更多相关视频
09:54Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
Published on: March 8, 2020
5.3K
08:37Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
Published on: June 25, 2019
8.1K
相关概念视频
Substance Use Disorders Affecting Sleep
216
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
216
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
366
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
366
Opioid Receptors: Overview
1.8K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.8K
Sleep Apnea
218
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
218
