影响慢性自发性疹治疗坚持的因素:系统性审查
Aditya Joshi1,2, Lauren Gawey1, Muhammad Rahman1
1Department of Dermatology, University of Washington School of Medicine, 1959 NE Pacific St., Suite BB-1332, Health Sciences Building (HSB), Box 356524, Seattle, WA, 98195-6524, USA.
Clinical reviews in allergy & immunology
|July 31, 2025
概括
改善慢性自发性疹 (CSU) 的坚持要求解决患者相关,治疗相关和医疗保健系统障碍. 多方面,以患者为中心的策略可以增强CSU患者的治疗参与度和治疗结果.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 慢性自发性疹 (CSU) 呈现出反复的/血管,没有明确的触发因素.
- 在CSU管理中,低于最佳的治疗坚持是重大挑战,影响症状控制和生活质量.
- 像奥马利祖马布这样的生物疗法已经推进了CSU治疗,但坚持仍然是一个障碍.
研究的目的:
- 系统地审查关于慢性自发性疹 (CSU) 坚持的文献.
- 确定导致CSU患者不坚持治疗的障碍.
- 提出基于证据的策略,以改善长期治疗坚持和参与CSU.
主要方法:
- 使用相关关键词进行了PubMed和EMBASE (2000-2024) 的系统文献搜索.
- 研究被选和分类基于世卫组织的遵守维度.
- 遵循偏差风险评估和PRISMA指南;与PROSPERO注册的协议.
主要成果:
- 包括21项涉及18500名患者的研究.
- 常见的坚持障碍包括药物不便,遗忘,提供者不满以及生物管理物流.
- 高等教育,就业和支持资源等因素与更好的遵守相关,而COVID-19影响了获取.
结论:
- 多个相互关联的障碍阻碍了CSU的治疗坚持.
- 以患者为中心的干预措施,简化方案和加强沟通至关重要.
- 远程医疗,家庭管理和支持计划可以改善坚持和长期结果.
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