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用于更年期激素治疗的雌激素和选择性雌激素受体调节剂 (SERM) 的比较

Frank Z Stanczyk¹, Jane L Yang¹, Herjan J T Coelingh Bennink²

¹Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Menopause (New York, N.Y.)

|July 31, 2025

概括

更年期激素治疗 (MHT) 使用雌激素和选择性雌激素受体调节器 (SERM) 来治疗症状和骨密度. 建议采用个性化的方法来选择最佳的MHT选项.

科学领域:

内分泌学在内分泌学.
药理学药理学是指药理学的学科.
妇女健康妇女健康

背景情况:

更年期激素治疗 (MHT) 涉及类固醇雌激素和选择性雌激素受体调节器 (SERM).
通常使用的药物包括结合性马类雌激素 (CEE),雌醇 (E2),他莫西芬和拉洛西芬.
这些药物在雌激素受体亲和力和药理动力学上有所不同,影响了临床使用.

研究的目的:

审查用于MHT的各种雌激素和SERM的疗效和安全性.
突出这些药物对更年期症状,骨密度和癌症风险的影响.
讨论潜在的风险,如静脉血栓塞栓症和埃斯特醇 (E4) 的新兴作用.

主要方法:

对MHT的雌激素和SERM现有文献的审查.
分析不同药物的药理动力学和药理动力学特性.
评估临床试验数据的疗效,安全性和特定结果,如血管运动症状,骨密度和癌症风险.

主要成果:

雌激素 (CEE,E2) 对血管运动症状 (VMS),更年期的生殖尿综合征 (GSM) 和骨密度有效.
SERM对VMS和GSM有不同的影响,但用于骨质疏松症和乳腺癌预防 (tamoxifen,raloxifene).
乙醇 (E4) 显示对静脉瘤,肌肉瘤和骨有有益影响,对乳腺和血液静止有中性影响;一些药物携带静脉血栓栓塞的风险.

结论:

雌激素和SERM为更年期管理提供了多种不同的治疗选择.
乙醇 (E4) 是一种新的选择,具有潜在的良好的安全性.
基于个体资料的个性化MHT选择对于最佳结果和风险减轻至关重要.

关键词:

雌激素是一种雌激素.绝经期的荷尔蒙治疗.药理动力学是什么药理动力学药理动力学药理动力学绝经后的妇女绝经后的妇女这就是SERMs.

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