脊髓损伤后针对大脑:针对性深度大脑刺激改善了受伤后的行走
Newton Cho1,2
1École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Science (New York, N.Y.)
|July 31, 2025
概括
针对性深度大脑刺激 (DBS) 提供了一种有希望的方法来改善神经损伤后的行走功能. 这种创新疗法旨在恢复受影响个体的运动控制和改善运动能力.
科学领域:
- 神经科学
- 康复医学
- 生物医学工程
背景情况:
- 神经损伤通常会导致严重的运动障碍,特别是影响步行和行走能力.
- 目前的康复策略在恢复像走路这样复杂的运动功能方面存在限制.
- 深度大脑刺激 (DBS) 是一种成熟的神经调节技术,有可能治疗运动障碍.
研究的目的:
- 研究针对性深度大脑刺激 (DBS) 改善受伤后的行走效果.
- 评估DBS对步态参数和运动恢复的影响.
- 探索DBS作为恢复行走的治疗干预的潜力.
主要方法:
- 一组受伤后走路障碍的患者接受了针对性的DBS.
- 通过神经成像指导电极放置到参与运动控制的特定大脑区域.
- 在干预之前和之后进行了步行分析,以量化行走参数的变化.
- 评估了功能结果和患者报告的运动能力.
主要成果:
- 有针对性的DBS导致了关键步行指标的显著改善,包括速度,步伐长度和稳定性.
- 在外行后,患者表现出更好的运动控制和协调能力.
- 显著比例的参与者表现出有意义的步行功能恢复.
结论:
- 针对性深度大脑刺激是改善神经损伤后行走能力的可行和有效策略.
- DBS有助于促进神经康复和恢复功能性移动.
- 需要进一步的研究来优化步态恢复的DBS协议.
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