主观记忆抱怨与90岁或以上的神经病变的关联:90+研究
Zarui A Melikyan1, Zeinah Al-Darsani2, Katherine A Colcord3,4
1Department of Neurobiology and Behavior, University of California, Irvine.
Neurology
|July 31, 2025
概括
在具有正常认知能力的老年人中,主观记忆问题 (SMC) 与阿尔茨海默病和血管变化有关. 这些发现表明,老年人的记忆问题背后存在多因素病理.
科学领域:
- 神经学 神经学
- 老年学是指老年学的学科.
- 病理学 病理学 病理学
背景情况:
- 主观记忆投诉 (SMCs) 是对记忆衰退的感知.
- SMCs与阿尔茨海默氏症 (AD) 神经病理学有关.
- 不太了解SMC与非AD病理以及在认知正常与受损个体之间的关联.
研究的目的:
- 研究SMC与神经退行性/血管神经病理变化之间的关联.
- 为了检查这些协会在最老的老年人 (90+年) 在死亡时没有痴呆症.
- 为了区分那些具有正常认知的发现与没有痴呆症 (CIND) 的认知障碍.
主要方法:
- 分析了90+研究中的数据,这是一项纵向衰老研究.
- 包括SMC评估,死亡时没有痴呆症和神经病理学检查的参与者 (n=238).
- 逻辑回归用于估计12个神经病理变化的几率比率,调整为共变量.
主要成果:
- 在整个组中,SMC与动脉样硬化的更高几率有关.
- 在认知正常的个体中,SMC与AD神经病理学,Lewy体疾病和动脉样硬化的更高几率有关.
- 在患有CIND的个体中,SMC和神经病理变化之间没有发现显著的关联.
结论:
- 在具有正常认知的老年人中,SMC与神经退行性和血管神经病理变化有关.
- 这些发现表明,这群人群中SMC背后的病理是多因素的.
- 在老年人中,SMC可以作为潜在大脑变化的早期指标.
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