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Updated: Jun 23, 2026

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结合性转录基因和单细胞蛋白质对结直肠癌的表征描绘了与整体存活率相关的独特的瘤免疫微环境

Erika Hissong1, Bhavneet Bhinder2, Junbum Kim2

  • 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 525 E 68th St, New York, NY 10065, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian, 413 E 69th St, New York, NY 10021, USA.

Pathology, research and practice
|July 31, 2025
PubMed
概括

结直肠癌 (CRC) 中的瘤免疫微环境 (TIME) 显著影响患者的治疗结果. 一个由特定的免疫细胞和结构特征的激活的TIME与CRC患者的生存率改善有关.

关键词:
结肠直肠癌是一种癌症.质量细胞计量 (Mass cytometry) 是一种测量质量细胞的方法.瘤微环境是一个微环境.

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors08:32

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...