对年轻成年人的血管衰老负担的洞察力,其中包括源不明的栓塞性中风
Nikolaos Kakaletsis1, Daniel Gordin2, Nicolas Martinez-Majander1
1Department of Neurology, Helsinki University Hospital and University of Helsinki, Finland.
Journal of the neurological sciences
|July 31, 2025
概括
源不明的栓塞性中风 (ESUS) 的年轻人表现出早期血管衰老和心血管疾病 (CVD) 风险增加. 像PREVENT和SCORE2这样的临床评分可以识别高风险个体,帮助预防中风的早期干预.
科学领域:
- 血管生物学和医学 血管生物学和医学
- 心血管研究研究心血管研究
- 神经学和中风研究 神经学和中风研究
背景情况:
- 源不明的栓塞性中风 (ESUS) 影响年轻成年人,需要对潜在的动脉样硬化前变化进行调查.
- 了解年轻ESUS患者的血管衰老对于识别心血管疾病 (CVD) 的早期迹象至关重要.
研究的目的:
- 为了比较前动脉样硬化变化,血管衰老标志物和年轻ESUS患者的心血管疾病风险得分与无中风对照.
- 评估临床风险评分在识别ESUS风险的年轻成年人中的有用性.
主要方法:
- 一项病例控制研究,涉及105名年轻ESUS患者和105名年龄/性别匹配的对照 (18-49岁).
- 收集了临床,实验室和动脉硬度测量,包括内心介质厚度 (IMT) 和估计的脉冲波速度 (ePWV).
- 使用逻辑回归计算和分析了血管衰老指数和临床心血管疾病风险得分 (PREVENT,SCORE2).
主要成果:
- 年轻的ESUS患者表现出更高的中央肥胖率,吸烟,饮酒和卵孔.
- 在ESUS患者中,过度IMT,升高的ePWV和高脉压 (PP) 的几率显著更高.
- 在使用PREVENT (>5%) 和SCORE2 (>2.5%) 评分的ESUS患者中观察到更高的10年心血管疾病风险.
结论:
- 年轻的ESUS患者表现出显著的血管衰老病理 (IMT,ePWV,PP),尽管已确定的心血管疾病负担较低.
- 临床风险评估工具如PREVENT和SCORE2在识别ESUS风险较高的年轻人方面是有效的.
- 在高风险的年轻人中,早期识别和干预可以预防未来的中风事件.
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