在患有肠衰竭的儿童中相角的实用性
Dianna Yanchis1, Abina Chandrakumar2, Stephanie So3
1Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, ON, Canada.
患有肠衰竭的儿童表现出较低的相角,这是细胞完整性的生物标志物. 这一测量与肌肉质量和力量相关,表明其潜在的临床实用性.
科学领域:
- 儿科健康中的生物标志物
- 细胞膜的完整性和功能.
- 在重症监护中的营养评估.
背景情况:
- 来自生物电阻分析 (BIA) 的相角是细胞膜完整性的潜在生物标志物.
- 较低的相角值可能表明细胞健康状况发生变化,在营养不良和疾病等情况中具有相关性.
- 它在儿科肠道衰竭中的作用需要进一步调查.
研究的目的:
- 为了在患有肠道衰竭的儿童中比较相角,与健康对照进行比较.
- 调查这一群体中相角和营养状况之间的关联.
- 探索相角作为肌肉质量和力量的潜在指标.
主要方法:
- 一项针对68名患有肠衰竭的儿童 (1-18岁) 的前性,描述性横截面研究.
- 使用BIA计算的相角;通过人体测量和双能X射线吸收测量评估营养状况.
- 用于力量和体力活动评估的手握强度和加速度计.
主要成果:
- 与文献对照组 (6.0) 相比,患有肠衰竭的儿童表现出明显较低的相角 (5.0).
- 阶段角与中上臂周长,手握强度和中上臂肌肉周长有显著的关联.
- 关联是年龄的积极介导.
结论:
- 阶段角度可以提供洞察力,以肌肉质量和力量的孩子与肠道衰竭,超出传统的评估.
- 需要进一步的研究来验证其在这个人群中的临床应用.
- 阶段角显示出作为细胞健康和营养状况的非侵入性指标的前景.
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