阐明口腔下纤维化病变的发生:综合性综述
Disha Sharma1, Sarita Pal1, Uma Shanker Pal2
1Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Near Kukrail Picnic Spot Road, Lucknow, Uttar Pradesh 226015, India.
Archives of oral biology
|July 31, 2025
概括
口腔下粘膜纤维化 (OSMF) 涉及复杂的细胞和分子通路,导致口腔癌. 了解这些机制,包括生长因素和信号通路,对于开发OSMF的向疗法至关重要.
科学领域:
- 口腔病理学 口腔病理学
- 癌症生物学 癌症生物学
- 分子机制的分子机制
背景情况:
- 口腔下粘膜纤维化 (OSMF) 是一种先发性口腔疾病.
- 它的特点是渐进的纤维化和炎症.
- OSMF显著增加了恶性转变为口腔癌的风险.
研究的目的:
- 审查OSMF病变发生的关键机制.
- 探索细胞参与者,生长因子和信号通路在OSMF进展中的作用.
- 了解OSMF转化为口腔癌的过程.
主要方法:
- 通过PubMed,Scopus,Google Scholar和SciFinder进行全面的文献搜索.
- 识别涉及OSMF和口腔癌的细胞机制,通路和生长因子.
- 关于连续事件和路径相互连接的信息的综合.
主要成果:
- OSMF的进展涉及肌纤维细胞激活和上皮细胞,内皮细胞,免疫细胞和纤维细胞的功能改变.
- 关键的生长因子 (TGF-βs,PDGF,FGF,VEGF,CTGF) 和信号通路 (PI3K/AKT,JAK/STAT,WNT/β-catenin,NF-кB) 都与此有关.
- 这些途径驱动OSMF的启动,进展和恶性转变.
结论:
- 信号通路,特别是TGF-β和PI3K/AKT,提供潜在的治疗点和生物标志物.
- 这些通路调节了纤维细胞激活,炎症和OSMF中的原循环等关键过程.
- 对这些信号级联的进一步研究对于新的OSMF和口腔癌治疗至关重要.
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