前额叶皮质在听觉 - 语言幻觉中的作用:演员还是被动旁观者?
Kenneth Hugdahl1, André Aleman2
1Department of Biological and Medical Psychology, University of Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Neuroscience and biobehavioral reviews
|July 31, 2025
概括
精神分裂症和听觉语言幻觉 (AVH) 可能源于动态大脑网络调节的失败,而不仅仅是前额叶皮层 (PFC) 的低或高额度. 这种动态的相互作用是理解AVH的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 前额叶皮层 (PFC) 已与精神分裂症和听觉语言幻觉 (AVH) 有关.
- 早期的模型暗示PFC的 hypofrontality,把它视为一个被动的旁观者在调节内部产生的冲动.
- 最近的网络连接研究表明PFC的超前性,表明它发挥了积极的作用.
研究的目的:
- 审查和综合目前对PFC在精神分裂症和AVH中的作用的理解.
- 在AVH中探索PFC功能,记忆和现实监控之间的关系.
- 提出一种新模式,强调在AVH产生的动态互联网监管.
主要方法:
- 在精神分裂症和AVH中对PFC功能的文献综述.
- 讨论记忆过程和现实监控缺陷.
- 分析网络连接性研究和皮质网络的动态调节.
主要成果:
- 无论是 hypofrontality 还是 hyperfrontality 的模型都可能过分简化了 PFC 在 AVH 中的作用.
- AVH可能是由负面情绪记忆的入或现实监测中的失败引起的.
- 网络间动态的调节受损是AVH的一个关键因素.
结论:
- 任务积极和任务消极皮质网络之间的动态相互作用对于理解精神分裂症和AVH至关重要.
- 对于AVH来说,无法动态调节这些大规模网络是核心问题.
- 从静态的hypo/hyperfrontality转向动态的网络监管提供了一个更全面的观点.
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