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化学素刺激的HSP90AB1 SUMOylation促进单细胞激活和ERK1/2通过β2整合素的酸化

Lili Wu1, Guona Chen2, Fan Wu2

  • 1Laboratories of Thrombosis and Vascular Biology, Suzhou Ninth Hospital affiliated to Soochow University, Suzhou, Jiangsu, China; Cyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China.

Cellular signalling
|July 31, 2025
PubMed
概括

化学素通过增加蛋白质的SUMOylation (小型泛胺类修饰剂) 来增强动脉样硬化中的单细胞粘附,从而激活ERK1/2酸化. 抑制SUMOylation可以逆转这些效应,揭示了一个新的治疗点.

关键词:
动脉样硬化是一种动脉样硬化.化学是化学的,是化学的.在 HSP90AB1 SUMOylation 过程中,一个单细胞激活激活.在SUMO2/3中,你会得到三分之二.

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