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Ryan Osgueritchian¹, Vivek P Jani², Hoda Mombeini¹

¹Division of Cardiology, Johns Hopkins University, Baltimore, Maryland.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

|July 31, 2025

概括

已建立的风险评分为系统性硬化症相关的肺动脉高血压 (SSc-PAH) 提供了有限的预后. 声心图RV-PA合指标显著改善了SSc-PAH患者的死亡风险预测.

科学领域:

心脏病学心脏病学
肺部病理学肺部病理学
类风湿病学类风湿病学

背景情况:

肺动脉高血压 (PAH) 显著增加患病率和死亡率,特别是在患有全身性硬化症 (SSc) 的患者中.
右心室 (RV) 适应肺动脉 (PA) 后负荷对于SSc相关的PAH (SSc-PAH) 的结果至关重要.
现有的临床风险评分在预测SSc-PAH方面表现不清楚.

研究的目的:

评估已确定的PAH风险得分与SSc-PAH死亡率的关联.
为了确定心声波RV-PA合指标是否增强SSc-PAH的风险歧视.

主要方法:

对174名SSc-PAH患者进行了回声心脏图谱的回顾性分析.
对COMPERA 2.0,REVEAL 2.0,REVEAL Lite 2和法国的非侵入性标准进行评估.
评估RV全球纵向应变和RV自由壁应变 (RVFWS) 对RV-PA合正常化为PA缩压 (PASP).

主要成果:

确定的风险得分显示,对于1年死亡率 (C指数0.6640.751) 存在适度的歧视.
纳入RV-PA合指标 (RV/PASP) 显著改善了死亡率预测 (P < .05).
在所有评估的风险分数中,RV-PA合参数在预测准确度上取得了最大的增长.

结论:

目前的风险评分对SSc-PAH的1年死亡率预测能力有限.
声心图RV-PA合参数显著提高了SSc-PAH的风险评估.
这种非侵入性方法提升了这个高风险患者群体的预后.

关键词:

心声回声扫描 (Echocardiography) 是一种心声回声扫描.死亡率死亡率死亡率肺动脉高血压是肺动脉高血压.右心室的右心室.脊髓硬化症是什么脊髓硬化症

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