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发现了针对病毒蛋白酶的宽谱抗病毒药物,使用in silico结构建模和细胞分析

Dharmeshkumar Patel1, Ramyani De1, Niloufar Azadi1

  • 1Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.

Antiviral research
|July 31, 2025
PubMed
概括

新的广泛抗病毒药物NIP-22c和CIP-1针对病毒蛋白酶. 这些新型抑制剂对SARS-CoV-2,诺病毒,肠病毒和鼻病毒表现出纳米分子功效,为未来的流行病准备提供了希望.

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Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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