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在teprotumumab治疗的甲状腺眼病中,眼模式和手术结果:来自单中心研究的见解

Hannah L Walsh¹, Bashaer Aldhahwani², Charlotte Tibi²

¹University of Miami Miller School of Medicine, Miami, Florida.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

|July 31, 2025

概括

在甲状腺眼病 (TED) 患者中,teprotumumab 降低了垂直斜视,但没有影响水平偏差. 在接受teprotumumab治疗的TED患者中,对眼的手术结果与未接受药物治疗的患者相似.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

甲状腺眼病 (TED) 可能导致,影响患者的生活质量.
德杜马布 (Teprotumumab) 是TED的一种新的治疗方法,但它对视的作用尚未完全理解.

研究的目的:

为了研究与teprotumumab治疗的TED患者的视模式.
为了评估在接受teprotumumab治疗的TED患者中眼手术的感觉运动结果.

主要方法:

在2014年至2023年期间,对28名TED患者治疗teprotumumab的医疗记录进行了回顾性审查.
将眼手术结果与以前一组未接受teprotumumab治疗的TED患者进行比较.

主要成果:

采用teprotumumab治疗导致垂直斜视的显著减少 (P=0.023) 但水平斜视并没有显著减少.
所有患者都经历了teprotumumab后的持久性双眼视,通过镜或手术进行管理.
在接受teprotumumab治疗的患者中,眼手术的成功率为73%的双眼眼缓解,与未接受治疗的患者相比.

结论:

在TED患者中,teprotumumab有效地减少了垂直偏差.
在接受teprotumumab治疗的TED患者中,眼手术的结果与未接受治疗的患者的结果相似.
需要进行进一步的研究,以优化对TED视障的管理策略.

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