天龙凯chuanling通过DNMT3A-GSDMD对内皮细胞灭的轴依赖调节改善了COPD-PH
Huihua Li1, Zhenqiu Li1, Jing Gong1
1Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China.
Journal of ethnopharmacology
|July 31, 2025
概括
天龙凯chuanling (TL) 通过减少炎症和热致死来改善COPD-PH的肺功能. 它针对DNMT3A-GSDMD通路,为这种严重疾病提供了潜在的新疗法.
科学领域:
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 慢性阻塞性肺病与肺高血压 (COPD-PH) 是一种严重的并发症,预后不佳,治疗选择有限.
- 传统中医药化合物天龙 (TL) 用于肺部,但其机制尚不清楚.
研究的目的:
- 研究TL对COPD-PH的治疗作用.
- 阐明TL在COPD-PH中的作用背后的分子机制.
主要方法:
- 建立了一种使用香烟烟雾,LPS和缺氧的小鼠COPD-PH模型.
- 评估肺功能,炎症标志物 (TNF-α,IL-1β,IL-6,IL-18) 和他的病理学.
- 研究了DNMT3A,GSDMD,Caspase1和NLRP3的表达通过免疫组织化学,qPCR,免疫光学和西部斑在体内和体外 (HPAECs).
主要成果:
- 在COPD-PH小鼠中,TL治疗改善了肺功能,降低了右心室缩压 (RVSP) 和右心室缩指数 (RVHI).
- 通过降低DNMT3A和GSDMD的表达,TL减轻了肺炎和抑制了内皮皮质亡.
- 确定了DNMT3A和GSDMD在热症中的监管相关性.
结论:
- 通过抑制内皮质皮质灭亡,TL改善了COPD-PH的进展.
- 该机制涉及针对DNMT3A-GSDMD信号通路.
- TL提出了一种潜在的治疗策略,用于治疗COPD-PH.
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