外围瘤神经微环境:解读神经景观和用于治疗创新的机制性见解
Xiaoxiao Wang1, Yuetong Pan1, Yanting Zhou1
1Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Critical reviews in oncology/hematology
|July 31, 2025
概括
周围神经系统 (PNS) 在癌症的发展和进展中起着关键作用. 了解瘤微环境 (TME) 中的神经瘤相互作用为癌症提供了新的治疗策略.
科学领域:
- 癌症神经科学 癌症神经科学
- 周围神经系统生物学 周围神经系统生物学
- 瘤微环境研究 研究
背景情况:
- 周围神经系统 (PNS) 越来越多地被认为在癌症中的作用.
- 在瘤微环境 (TME) 中的神经瘤相互作用会影响癌症的进展和转移.
- 现有研究强调需要了解PNS对癌症发病因子的贡献.
研究的目的:
- 探索PNS在瘤微环境 (TME) 中的作用.
- 概念化瘤神经微环境 (TNME) 和它的动态.
- 审查针对癌症治疗的定向PNS干预措施的进展.
主要方法:
- 文献综述和综合癌症神经科学当前研究.
- 瘤神经微环境 (TNME) 框架的概念化.
- 神经与瘤相互作用的分析及其机制性见解.
主要成果:
- PNS通过神经瘤相互作用显著影响癌症的发病,进展和转移.
- 在TME中神经活动重塑免疫微环境并促进瘤原体扩张.
- 癌细胞,神经元和施万细胞之间的相互作用创造了一个动态的TNME.
结论:
- PNS是瘤神经微环境 (TNME) 的关键组成部分.
- 有针对性的PNS干预措施显示出新型癌症治疗的前景.
- 需要进一步研究以神经科学为导向的癌症治疗策略.
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