在2008年至2020年期间,在实体器官移植接受者的侵入性Candida感染
Lilly Meyer1, Jaromil Frossard2, Peter W Schreiber1
1Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
概括
侵入性角膜病 (IC) 影响4.3%的实体器官移植接受者 (SOTr),随着时间的推移,发病率下降. 死亡率仍然很高,特别是在肝脏和心脏移植患者以及候选血症患者中.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学 移植医学
- 流行病学 流行病学
背景情况:
- 关于固体器官移植受体 (SOTr) 侵袭性候群病 (IC) 的数据很少.
- IC对SOTr构成重大威胁,影响其长期结果.
研究的目的:
- 描述SOTr中IC的流行病学和结果.
- 分析IC发病率和相关死亡率的趋势.
- 为了告知SOTr的未来预防策略.
主要方法:
- 追溯的多中心队列研究.
- 利用了来自瑞士移植队列研究 (2008-2020) 的数据.
- 分析了4755个SOTr,确定了262次IC.
主要成果:
- 一年内IC的累积发病率为2.8%,随着时间的推移显示下降趋势.
- 腹部内感染比候选血症更为常见.
- 所有原因的12周死亡率为23.5%,肝脏和心脏移植接受者和候选血症患者的死亡率更高.
结论:
- 侵袭性白病发病率正在下降,但在SOTr中仍然很高.
- 死亡率很高,特别是在特定的移植类型和候选血症中.
- 这些发现支持在SOTr护理中加强预防和治疗策略的需要.
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