在非人类灵长类动物进口后隔离期间进行的结核病检测的特征,美国,2021年至2024年
Samantha D Swisher1,2, Sara J Taetzsch1, Mark E Laughlin1
11Division of Global Migration Health, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
概括
对进口的非人类灵长类动物进行结核病 (TB) 查至关重要. 虽然像TST和IGRA这样的常见测试显示出差异,但酸性细菌染色和PCR在NHP中为结核病检测提供了高预测价值.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 灵长类健康 灵长类健康
背景情况:
- 在非人类灵长类动物 (NHPs) 中进行结核病 (TB) 查对于殖民地和人类健康至关重要,特别是对于进口动物.
- 存在各种结核病检测方法,但它们在NHP中的性能需要进一步描述.
- 美国疾病控制和预防中心 (CDC) 要求对进口NHP进行结核病检测.
研究的目的:
- 评估不同结核病检测方法在进口NHP中的性能和一致性.
- 用文化作为黄金标准来评估诊断准确性.
- 确定可靠的方法,用于结核病查和诊断在NHPs.
主要方法:
- 从进口的NHP中收集的结核病检测结果 (TST,IGRA,MFIA,PCR,AFB染色,培养) 在CDC隔离 (FY2021-2024).
- 分析了测试性能和测试间协议.
- 用文化作为黄金标准进行比较.
主要成果:
- 结核素皮肤测试 (TST) 和干扰素γ释放测试 (IGRA) 显示彼此和培养的一致性不佳.
- 与培养相比,酸快细菌 (AFB) 染色和PCR显示出中等一致性和高正预测值.
- 肺部和气管支气管淋巴结是最常受到影响的组织.
结论:
- 目前的死前结核病测试 (TST,IGRA) 在进口的NHP中存在局限性.
- AFB染色和PCR显示出作为可靠的诊断工具的承诺,提供高的积极预测值.
- 需要进一步的研究来开发和验证对NHPs的改进的死前结核病查方法.
关键词:
AFB,酸性快速菌美国疾病预防控制中心,美国疾病控制和预防中心.财政年度,财政年度.IGRA,干扰素-γ释放测定试验LTBI,潜伏的结核病感染.MFIA,多重度免疫检测试验.MOT,哺乳动物老结核素.MTBC,Mycobacterium结核病综合体的使用美国农业部国家兽医服务实验室 (NVSL)结核病,结核病,结核病等疾病.TST,结核素皮肤试验全基因组测序 (WGS),全基因组测序更多相关视频
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