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农药诱导的嗅觉功能障碍:不良结果,新出现的机制和神经退行性疾病的风险

Lin Wang¹, Si-Yang Liu¹, Han-Yue Zheng¹

¹School of Life Sciences, Chongqing University, Chongqing 400044, China.

Pesticide biochemistry and physiology

|July 31, 2025

概括

农药暴露会导致神经损伤,特别是嗅觉功能障碍 (OD). 模型动物揭示了不平衡和亡等机制,为人类神经退行性疾病 (ND) 和潜在生物标志物提供了洞察力.

科学领域:

环境毒理学环境毒理学
神经科学是一个神经科学.
生态毒理学生态毒理学

背景情况:

农药污染是一个日益严重的全球性问题,具有既定的神经毒性.
嗅觉系统对生存行为至关重要,对农药破坏非常敏感,导致嗅觉功能障碍 (OD).
农药暴露与OD和神经退行性疾病 (NDs) 的恶化有关.

研究的目的:

系统地审查杀虫剂诱导的人类,小鼠,鱼类和昆虫的OD的发生和不良结果.
在模型动物中概述OD的新兴机制,重点关注平衡和神经元亡.
探索模型动物在理解OD相关生物标志物的作用,以早期诊断神经退行性疾病.

主要方法:

对有关农药诱导的嗅觉功能障碍的现有文献进行系统审查.
在模型生物 (小鼠,鱼,昆虫) 中研究OD机制的研究分析.
检查连接农药暴露,OD和神经退行性疾病的流行病学证据.

主要成果:

暴露于杀虫剂显然会导致各种物种的嗅觉功能障碍.
关键的机制包括平衡中断和诱导神经元亡.
在模型动物中的发现为人类的OD及其与神经退行性疾病的联系提供了宝贵的见解.

结论:

农药诱导的嗅觉功能障碍是一个重要的健康问题,在物种之间保留了机制.
模型动物对于阐明OD病原体和识别神经退行性疾病的潜在生物标志物至关重要.
需要进一步的研究来将模型生物的发现转化为早期ND诊断的临床应用.

关键词:

动物动物动物动物动物动物环境中的度环境中的度神经退行性疾病的神经退行性疾病嗅觉功能障碍嗅觉功能障碍杀虫剂是一种杀虫剂.

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