[在不同类型的慢性鼻炎中对二次嗅觉功能障碍的影响因素的分析]
Lingyan Han1, Junhao Wang2, Xiaofeng Qiao1
1The Otolaryngology Head and Neck Surgery Department of Shanxi Provincial People's Hospital,Shanxi Medical University,Taiyuan,030001,China.
概括
长期鼻多性鼻炎 (CRSwNP) 的嗅觉功能障碍与血液中异敏细胞,BUN和嗅觉区域CT得分有关. 在没有鼻息肉的慢性鼻炎 (CRSsNP) 中,它与血液单细胞和后部区域CT得分有关.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 嗅觉功能障碍是慢性鼻炎 (CRS) 的常见并发症.
- 不同的CRS亚型,特别是带鼻息肉的慢性鼻炎 (CRSwNP) 和没有鼻息肉的慢性鼻炎 (CRSsNP),可能具有不同的影响嗅觉障碍的因素.
研究的目的:
- 调查导致CRSwNP.患者嗅觉功能障碍的特定因素.
- 为了确定与CRSsNP患者的嗅觉功能障碍相关的因素.
- 在不同CRS亚型中开发和验证嗅觉功能障碍的预测模型.
主要方法:
- 对185名CRS患者的回顾性分析.
- 将患者分为CRSwNP和CRSsNP组,根据嗅觉状态进一步划分.
- 将一般数据,实验室检测 (血中乙,血尿素,血单细胞) 和修改的鼻腔CT得分进行比较.
- 用于预测分析的物流回归和名ogram模型开发.
主要成果:
- 在CRSwNP中,嗅觉功能障碍的独立因素包括血液中乙氨基酸比例,血液尿素和嗅觉区域CT得分.
- 在CRSsNP中,独立的因素是血液单细胞比例和后部区域CT得分.
- 开发的诺米图模型显示了CRS亚型的良好诊断性能,校准和临床实用性.
结论:
- 在CRSwNP中嗅觉功能障碍与全身炎症标志物 (乙素,BUN) 和嗅觉区域局部CT发现有关.
- 在CRSsNP中嗅觉功能障碍与特定的炎症标志物 (单细胞) 和后鼻区域的CT发现有关.
- 已建立的预测模型为早期识别和CRS患者嗅觉功能障碍的风险评估提供了有价值的工具.
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