以叶酸为基础的双核Mn(II) 酸盐与2.2'-二二丁/1,10-南林作为针对结肠癌细胞的向抗癌剂
Mona S Ragab1, Marwa H Soliman2, Marwa M Sharaky3
1Department of Chemistry, Faculty of Science, Cairo University, P.O. 12613, Giza, Egypt. msragab@cu.edu.eg.
Scientific reports
|July 31, 2025
概括
合成和表征了两种新型的双核 ((II)) 合物,其中包含了叶酸离子. 这些酸盐通过诱导细胞和核变化,对叶酸受体阳性癌细胞,特别是结肠癌HCT116细胞表现出显著的细胞毒性.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 生物医学科学 生物医学科学
背景情况:
- 混合接体过渡金属合物由于各种应用而引起人们的兴趣.
- 双核 ((II) 合物具有独特的结合特性和潜在的治疗性质.
研究的目的:
- 合成和描述具有叶酸离子的新型双核 (((II) 合物.
- 评估这些酸盐对癌症细胞系的细胞毒性和抗癌机制.
主要方法:
- 合成双核Mn(II) 酸盐:[Mn2(FA) ((Bpy) 2 ((H2O) 2Cl2].7H2O和[Mn2(FA) ((Phen) 2 ((H2O) 2Cl2].7H2O. 这两种酸盐的合成方法是:
- 使用元素分析,FTIR,UV-vis,EI-MS,TGA和DFT计算进行表征.
- 通过SRB测定进行细胞毒性评估;包括伤口愈合,细胞循环分析和蛋白质表达分析在内的机制研究.
主要成果:
- 成功合成并阐明了两个双核Mn(II) 酸盐的结构,它们具有扭曲的八面体几何.
- 对叶酸受体阳性细胞系观察到显著的细胞毒性作用,对HCT116结肠癌细胞有显著影响.
- 有证据表明,Mn(II) 酸盐会诱导细胞亡,细胞循环停止,以及HCT116细胞的形态变化.
结论:
- 合成的双核Mn(II) 酸盐表现出强大的抗癌活性.
- 叶酸离子在向和增强癌细胞中细胞毒性的过程中起着至关重要的作用.
- 这些酸盐代表了在癌症治疗中进一步研究的有希望的候选人.
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