补充运动区域增强了在抑制性cTBS后对负载的血液动力学反应
Yongjun Qiao1, Dan Zhao1, Jin Yan2
1Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Scientific reports
|July 31, 2025
概括
在补充运动区域 (SMA) 上进行的抑制性横磁刺激 (cTBS) 并没有破坏大范围运动 (LEM) 期间肌肉负荷和大脑激活之间的关系. 在cTBS后,皮层对负荷的反应仍然可以预测.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 康复科学 康复科学 康复科学
背景情况:
- 大范围运动 (LEM) 对于日常生活至关重要,但它们在受伤后的恢复是具有挑战性的.
- 在LEM期间肌肉负荷可能会阻碍神经康复的进展.
- 抑制性连续甲基突破刺激 (cTBS) 可能有助于恢复,但可能会影响运动任务控制.
研究的目的:
- 调查负载和皮质激活之间的确定的线性关系是否在补充电机区域 (SMA) 上的cTBS后持续存在.
- 为在脑刺激干预过程中选择抵抗水平建立一个基准.
- 了解cTBS对SMA和M1血液动力学活动在不同负荷的LEM期间的影响.
主要方法:
- 功能近红外光谱 (fNIRS) 在LEM期间监测SMA和M1血液动力活动.
- 十二名健康的参与者接受了40多年的cTBS在SMA上.
- 参与者在cTBS之前和之后进行了重复的LEMs,重量为0,3和15磅.
主要成果:
- 在SMA上,cTBS导致左SMA和M1在举起0和3磅时皮质激活 (β) 的增加.
- 在cTBS后的左侧SMA,左侧M1和右侧SMA中,个体受试者变异性 (随机拦截) 增加.
- 负载和运动皮质激活 (斜坡) 之间的关系不受cTBS的影响.
- 在运动皮质激活拦截和参与者的年龄之间发现了正相关性.
结论:
- 补充运动区域 (SMA) 显示,尽管cTBS诱导抑制,但fNIRS对增加负载的反应持续或增强.
- 负载惯性和运动皮质激活之间的可预测的关系在cTBS超过SMA后得到保留.
- 这些发现表明,cTBS在LEM期间可能不会破坏运动皮质区域的基本负载响应特征,支持其在神经康复中的潜在用途.
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