人体肠道中常见细菌合成的多胺改善了动物的新陈代谢
Yong Fan1, Liwei Lyu1,2, Ruben Vazquez-Uribe3
1Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Nature microbiology
|July 31, 2025
概括
肠道细菌产生RUMTOR衍生 (RORDEPs),可以对抗肥胖和代谢疾病. 研究表明,RORDEPs可以提高葡萄糖耐受性,骨密度和脂肪质量,这表明其具有治疗潜力.
科学领域:
- 微生物学 微生物学
- 代谢科学 代谢科学
- 人体生理学 人体生理学
背景情况:
- 人体肠道微生物群合成影响宿主新陈代谢的蛋白质.
- 特定的肠道共生细菌,Ruminococcus torques,产生来自RUMTOR的 (RORDEPs).
- RORDEPs在人体血液中循环,与脂肪相反相关.
研究的目的:
- 为了研究RORDEPs的代谢作用.
- 探索RORDEPs在代谢障碍中的治疗潜力.
主要方法:
- 在小鼠体内口服检测RORDEP表达细菌.
- 在老鼠中使用复合RORDEP1 (腹腔内和肠道).
- 基因和蛋白质表达的分析与新陈代谢,热生成和脂解有关.
主要成果:
- 在小鼠中,表达RORDEP的细菌改善了葡萄糖耐受性,增加了骨密度,并减少了脂肪质量.
- 重组RORDEP1调节肠道激素 (GIP,GLP-1,PYY) 和大鼠的胰岛素水平.
- 肠道RORDEP1增强了肝脏中的胰岛素敏感性,调节了葡萄糖和脂质代谢.
结论:
- 由肠道细菌合成的RORDEPs在改善代谢参数方面显示出显著的临床前疗效.
- 这些发现支持探索RORDEP用于预防和治疗人类代谢障碍,如肥胖和2型糖尿病.
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