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Updated: Sep 13, 2025

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
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A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

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关于MKP5双特异性酸酶的全调节的动态和结构洞察力

Erin Skeens1, Federica Maschietto2,3,4, Ramu Manjula5

  • 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.

Nature communications
|July 31, 2025
PubMed
概括

双特异性蛋白质酸酶调节了线素激活蛋白激酶 (MAPKs). 这项研究揭示了MKP5s全位,特别是Y435残留物如何控制酶活性和MAPK结合,影响细胞信号通路.

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