西班牙裔社区的环境毒素在表观遗传上有助于产前
Lauren Rae Gladwell1, Laura Packer1, Jhanvi Karthik1
1Department of Pharmaceutical Sciences, Texas A&M Irma Lerma Rangel College of Pharmacy, College Station, TX, USA.
Cardiovascular toxicology
|July 31, 2025
概括
西班牙裔妇女面临更高的孕前率,可能是由于环境中毒物暴露. 本综述探讨了表观遗传学如何将这些暴露与这一人群中孕前的发展联系起来.
科学领域:
- 生殖健康 生殖健康
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 孕前是一种严重的妊娠并发症,影响母亲和婴儿的健康.
- 不平等存在,西班牙裔女性比非西班牙裔白人女性的比例更高.
- 这些差异的原因,特别是环境因素,仍然不清楚.
研究的目的:
- 调查环境毒素暴露在西班牙裔妇女产前症差异中的潜在作用.
- 探索可能调解毒素和产前之间的关系的表观遗传机制.
主要方法:
- 本综述综合了有关西班牙裔社区普遍存在的环境毒素的当前研究.
- 它考察了表观遗传学的原理及其对环境刺激的反应能力.
- 该审查提出了潜在的表观遗传途径,将毒性物质暴露与产前联系起来.
主要成果:
- 西班牙裔妇女面临不成比例的环境毒素暴露,如颗粒物,重金属,酸盐和微/纳米塑料.
- 表观遗传修饰,即改变基因表达而不改变DNA序列,可以受到有毒物质暴露的影响.
- 失调的表观遗传变化可能会导致孕前的发展.
结论:
- 暴露于环境中有毒物质是导致西班牙裔妇女妊娠前率较高的一个可能因素.
- 表观遗传学提供了一个潜在的机制,解释环境暴露如何导致孕前.
- 对这些表观遗传联系的进一步研究对于理解和解决健康差异至关重要.
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