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Updated: Jul 15, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

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乳酸酸抑制了通过AKT-PKM2轴的小鼠胚胎 palatal mesenchyme细胞的原生

Mingyue Meng1, Xige Zhao1, Xiaoyu Zheng1

  • 1Laboratory of Orofacial Development, Laboratory of Molecular Signaling and Stem Cells Therapy, Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Fan Jiacun Road No. 9, Beijing, 100071, China.

BMC oral health
|July 31, 2025
PubMed
概括

乳酸酸通过影响糖解和激活AKT-PKM2轴来抑制口腔软骨的发育. 这一发现为口腔裂病因和潜在的预防策略提供了新的见解.

关键词:
混凝土生成 (chondrogenesis) 是一种破裂的宫殿口.葡萄糖溶解是什么? 葡萄糖溶解氧气过低是因为缺氧.乳酸盐是一种乳酸盐.在 MEPM 细胞中,

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Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

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PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...