与自身免疫性获得的XIII因子缺乏症的结果进行比较,有或没有潜在疾病:系统性审查
Juanjuan Song1, Liu Liu2, Bingjie Ding1
1Department of Hematology, Henan Cancer hospital, Institute of Hematology of Henan Province, The Affiliated Cancer Hospital of Zhengzhou University, No.127 Dongming Road, Jinshui District, Henan, Zhengzhou, 450000, China.
Journal of thrombosis and thrombolysis
|July 31, 2025
概括
自免疫性获得的XIII因子缺乏症 (AiF13D) 是罕见的. 患有癌症或自身免疫性疾病等潜在疾病的患者比患有异常AiF13D的患者面临更严重的出血和更糟糕的结果.
科学领域:
- 血液学 血液学 血液学
- 自免疫性疾病 自免疫性疾病
- 罕见的出血疾病 罕见的出血疾病
背景情况:
- 自免疫性获得的XIII因子缺乏症 (AiF13D) 是一种罕见的出血障碍.
- 它可以是异常性或与恶性瘤或自身免疫性疾病等并发症相关.
- 只有有限的数据可以比较这些病因学子组.
研究的目的:
- 系统地审查和比较AiF13D的临床特征,治疗方法和治疗结果,包括患有和没有潜在疾病的患者.
- 为了识别与并发症相关的异常AiF13D和AiF13D之间的差异.
主要方法:
- 对病例报告,病例系列和队列研究的系统文献综述.
- 搜索了PubMed,科学网和Scopus数据库,直到2023年12月.
- 病因子组之间的临床特征,治疗和结果的比较.
主要成果:
- 患有潜在疾病的AiF13D组中女性患者更为常见.
- 患有潜在疾病的患者具有更高的抑制剂水平和更多的III级出血.
- 较少的患有潜在疾病的患者接受了组合治疗,并经历了更高的复发/死亡率.
结论:
- 与潜在疾病相关的AiF13D呈现出更严重的出血和较差的结果.
- 临床医生应在患有并发症的患者中对AiF13D保持警.
- 定期监测和及时治疗对于管理AiF13D至关重要.
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