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Updated: Sep 13, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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作为提高PROTAC口服生物可用性的策略,链接甲基化:从分子性质和形态分析的见解

Diego Garcia Jimenez1, Giuseppe Ermondi1, Zuzana Jandova2

  • 1Molecular Biotechnology and Health Sciences Dept., Università di Torino, Piazza Nizza 44bis, Torino 10126, Italy.

Journal of medicinal chemistry
|August 1, 2025
PubMed
概括

流出比率有效预测VHL-based PROTACs的口服生物可用性,链接子甲基化影响了这一特性. 这一发现有助于预测在药物发现过程中PROTAC的口服吸收.

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