免疫adsorption作为一个救援治疗非常高的抗B滴度在ABO不兼容的脏移植
Chanyanuch Rakpithayanon1, Nattapakorn Mai-On1, Sirihatai Konwai1,2
1Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
The American journal of case reports
|August 1, 2025
概括
免疫吸附有效地降低了高抗B抗体标位在ABO不相容的脏移植当标准血酶失败时. 这种救援疗法为患者提供了更安全的替代方案,该替代方案对传统的非法具有抗性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
背景情况:
- 抗ABO不兼容 (ABOi) 移植带有抗体中介排斥的风险,原因是献血者血型抗体升高.
- 标准的脱敏方案包括抗体去除 (血化,双过血化) 和修复剂.
研究的目的:
- 报告第一个使用免疫吸附作为ABO不兼容移植中耐火抗B抗体标位的救援疗法的案例.
主要方法:
- 一名抗B标位高的患者 (1:2048) 接受了双过血化 (DFPP) 和修复药,这证明是无效的,导致出血.
- 然后采用特定抗B抗体免疫吸附作为救援策略.
主要成果:
- 免疫吸附成功地将抗B抗体标位降低到移植前的1:32.
- 与ABO不相容的移植成功进行,没有并发症.
结论:
- 免疫吸附是一种有效的救援疗法,用于ABOi移植病例,这些病例对传统的异位反应有抗性.
- 这种方法允许更长的治疗时间,并最大限度地降低出血风险,改善了挑战性脱敏方案的结果.
更多相关视频
相关概念视频
Blood Transfusion
814
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
814
Kidney Transplant II: Surgical Procedure
76
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
76
Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
Blood Transfusion and Agglutination
11.2K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.2K
Kidney Transplant III: Nursing Management
82
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
82
Cell-mediated Immune Responses
72.9K
Overview
72.9K


