非洲人口多基因癌症风险评分:系统性审查
Wafaa M Rashed1, Olagunju Abdulrahmon A2
1Department of Clinical Pharmacy, Faculty of Pharmacy, Ahram Canadian University. 6th of October, Egypt.
Annals of human genetics
|August 1, 2025
概括
这次审查发现,在非洲血统的癌症患者中,基于全基因组关联研究 (GWAS) 的多基因风险评分 (PRS) 研究有限. 这些多基因风险评分 (PRS) 研究显示,与欧洲人口相比,临床效用较低,突出显示需要更多的研究.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 基因组流行病学 基因组流行病学
背景情况:
- 精准医学依赖于基因风险预测.
- 多基因风险评分 (PRS) 是评估对疾病的遗传倾向的新兴工具.
- 在基因组研究中,非洲祖先人口的代表性不足,这限制了PRS的开发和应用.
研究的目的:
- 在任何癌症类型的非洲祖先人群中,系统地审查基于全基因组关联研究 (GWAS) 的多基因风险评分 (PRS) 研究.
- 评估PRS在促进非洲人群治疗各种癌症的精准医学方面的临床实用性.
主要方法:
- 从2009年1月到2023年4月,PubMed的系统文献搜索.
- 包括基于全基因组关联研究 (GWAS) 的多基因风险评分 (PRS) 研究,针对非洲遗传祖先的癌症患者.
主要成果:
- 确定了33项符合条件的研究,其中前列腺癌和乳腺癌在成年人中最为普遍.
- 祖先特定的PRS是最常见的方法;临床效用各不相同,通常不一致.
- 对于非洲血统的癌症患者存在有限数量的PRS研究,显示其临床效用低于欧洲血统人群.
结论:
- 在非洲祖先种群中,急需更大规模的,特定于种群的GWAS.
- 改善非洲祖先队伍在基因组研究中的代表性至关重要.
- 完善PRS模型是必要的,以捕捉非洲人群中的遗传多样性,以获得临床可行性.
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