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结直肠癌中对新辅助化疗和放射治疗的反应的遗传决定因素,通过全外体测序识别

Jelena Peric1, Sandra Dragicevic1, Marko Miladinov2

  • 1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.

Annals of human genetics
|August 1, 2025
PubMed
概括

在局部晚期直肠癌 (LARC) 瘤中的遗传变异可以预测对新辅助化学放射治疗 (nCRT) 的反应. 特定的跨膜载体基因变异可能表明nCRT结果不佳.

关键词:
遗传变异 遗传变异是一种遗传变异.局部先进的直肠癌 局部先进的直肠癌新辅助性化疗或放射治疗.整体外基因组测序的测序

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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