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Updated: Sep 13, 2025

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
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Published on: October 1, 2010

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基尔6.2通道活动是由跨膜域1和2到I167之间的相互作用调节的,在捆绑交叉门中

Ryoko Kawashima1,2, Charlotte Meller3,4,5, Manabu Suzuki1

  • 1Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.

Physiological reports
|August 1, 2025
PubMed
概括

在Kir6.2中发生的突变,这是一种对ATP敏感通道的子单元,可以导致DEND综合征. I167L突变增加了通道开放,这表明I167稳定了开放状态.

关键词:
在KATP频道道上.在 Kir6.2 里.这里是SUR SUR.

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