老年波多黎各成人的肠道健康,药使用和认知功能
Deepika Dinesh1,2, Jong Soo Lee1,3, Tammy M Scott1,4
1Center for Population Health, University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Journal of aging research
|August 1, 2025
概括
肠道功能障碍,包括异常频率和药使用,与波多黎各成年人的认知功能下降有关. 然而,使用药并不能预测13年内认知功能的变化.
科学领域:
- 胃肠病学 胃肠病学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 肠道功能障碍和药的使用是胃肠道 (GI) 健康的指标.
- 这些因素与认知功能相反地相关.
- 在拉丁裔和西班牙裔人口中,关联的研究不足.
研究的目的:
- 检查肠道频率,便类型,药使用和认知功能之间的关联.
- 在波士顿波多黎各人健康研究 (BPRHS) 中调查了这些关系.
主要方法:
- 在1502名波多黎各成年人中进行了13年的前性队列研究.
- 使用全球认知分数 (GCS) 评估认知功能.
- 肠道健康 (频率,便类型) 和药使用是自我报告的.
主要成果:
- 在第4波中,高肠道频率与较低的GCS有关 (β = -0.152,p = 0.02).
- 药使用者在基线 (β = -0.13,p = 0.01) 和第4波 (β = -0.13,p = 0.05) 时具有较低的GCS.
- 药使用与13年内GCS的变化无关 (药使用*时间β = 0.006,p = 0.28).
结论:
- 低或高的肠道频率和药使用可能与认知功能相反相关.
- 在这个人群中表明肠道健康和认知健康之间的关系.
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