Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Unraveling the interplay of DNA methylation and chromosome organization.

Biochemical Society transactions·2025
Same author

Tet-mediated DNA methylation dynamics affect chromosome organization.

Nucleic acids research·2024
Same author

Rapid generation of maternal mutants via oocyte transgenic expression of CRISPR-Cas9 and sgRNAs in zebrafish.

Science advances·2021
Same author

Joint profiling of DNA methylation and chromatin architecture in single cells.

Nature methods·2019
Same author

DNA methylation reprogramming of functional elements during mammalian embryonic development.

Cell discovery·2018

相关实验视频

Updated: Sep 13, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K

空间模式增强的细胞和组织识别用于空间转录组学.

Yucen Wang1, Zhuoyu Zhang1, Guoqiang Li1

  • 1Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University, Beijing 100871, China.

NAR genomics and bioinformatics
|August 1, 2025
PubMed
概括

SPECTRUM 是一种用于分析空间转录组学数据的新工具. 它准确地识别了细胞类型和细胞群体,揭示了细胞通信如何塑造组织发育.

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 发展生物学 发展生物学

背景情况:

  • 空间转录学 (ST) 提供了对组织组织的洞察力,但需要专门的数据分析.
  • 了解细胞微环境对于破译复杂的生物系统至关重要.

研究的目的:

  • 开发一种统一的方法,SPECTRUM,用于分析空间转录学数据.
  • 增强ST数据集中的细胞类型识别和空间社区检测.
  • 研究细胞通信在人类四肢发育中的作用.

主要方法:

  • SPECTRUM集成了已知的细胞类型标记器与空间权重进行分析.
  • 该方法采用针对空间数据量身定制的统计和推理方法.
  • 通过全面的基准和真实ST数据集来验证性能.

主要成果:

  • SPECTRUM准确地绘制了特定区域的细胞类型和功能空间社区.
  • 与现有方法相比,该工具显示出更高的性能.
  • 分析揭示了依赖上下文的沟通支持细胞可塑性在发展人类四肢.

结论:

更多相关视频

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.7K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

3.2K

相关实验视频

Last Updated: Sep 13, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.7K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

3.2K
  • SPECTRUM提供了一个统一的方法,用于空间转录学数据分析.
  • 该工具增强了对分子,细胞和社区层面空间组织的理解.
  • 研究结果强调了细胞沟通在发育过程中的重要性.